Perioperative Lactate Kinetics in Patient Undergoing Major Liver Surgery

N/ACompletedNCT04512014

Institutul Clinic Fundeni55 enrolled

Overview

Major liver surgery is associated with increased incidence of perioperative complications and increased mortality if these are not addressed quickly in a high dependency intensive care unit. Of these, posthepatectomy liver failure (PHLF) represents one of the most important cause of postoperative unfavourable outcome. The present study investigates the correlation between lactate levels and PHLF. Lactate levels were collected at six specific timepoints: preoperative, pre-dissection phase, post-dissection phase, end of surgery and 24-hours and 48-hours in the postoperative period.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Liver Failure, Acute

Interventions

serum lactateDIAGNOSTIC_TEST

perioperative measurement of lactate levels

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing major liver surgery for primary or secondary tumours Exclusion Criteria: * unsigned patient consent * death within 24 hours * need for perioperative renal replacement therapy * underlying liver disease (e.g. liver cirrhosis) * other causes of raised lactate levels (e.g. shock)

Locations (1)

Fundeni Clinical Institute

Bucharest, Romania

Outcomes

Primary Outcomes

lactate levels (mmol/L) in patients with PHLF

correlation of lactate levels with the diagnosis of PHLF

Time frame: early postoperative period (48 hours)

Secondary Outcomes

mortality

in hospital mortality

Time frame: 30 days mortality

Data from ClinicalTrials.gov

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