Single-blind within subject comparison study conducted to investigate the skin protectant properties of Omeza Collagen Matrix on damaged skin
This study was conducted in 22 healthy subjects to determine the skin protectant and anti-inflammatory properties of the test product. For the skin protectant assay the test article was applied to the forearm and covered with gauze for 10 minutes before assessment of irritation and TEWL readings. An inflammatory skin response was induced by a SLS solution 24 hours prior to application of the test article. The test article was applied for 10 minutes at the site of inflammation. The test site was then graded for irritation and TEWL readings.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
22
Omeza Collagen Matrix
Princeton Research Corporation
Chelmsford, Essex, United Kingdom
Transepidermal Water Loss (TEWL)
Assessment of water evaporation (TWEL) based upon diffusion principle after 24 hour injury
Time frame: 24 hours
Transepidermal Water Loss (TEWL)
Assessment of water evaporation (TWEL) based upon diffusion principle
Time frame: 48 hours
Transepidermal Water Loss (TEWL)
Assessment of water evaporation (TWEL) based upon diffusion principle
Time frame: 72 hours
Transepidermal Water Loss (TEWL)
Assessment of water evaporation (TWEL) based upon diffusion principle
Time frame: 96 hours
Erythema
Irritancy Grading on a 0-4 scale
Time frame: 24 hours
Erythema
Irritancy Grading on a 0-4 scale
Time frame: 48 hours
Erythema
Irritancy Grading on a 0-4 scale
Time frame: 72 hours
Erythema
Irritancy Grading on a 0-4 scale
Time frame: 96 hours
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