Reward and Drug Effects on Mood and Brain Response

Inclusion Criteria: * must be able to give informed consent * age 18-25 at the time of signing the consent form * fluency in English * body mass index of 19-26 (normal/overweight but not obese due to limitations of MRI) * negative urine drug screen (UDS) for all substances except THC (THC allowed) * must be medically and neurologically healthy * must not be taking psychoactive medications that would interfere with dronabinol and/or interpretation of fMRI data, including but not limited to the following classes of psychotropics: antidepressants, anxiolytics, sedative hypnotics, stimulants, antipsychotics, mood stabilizer * have used cannabis at least 10 times in their life, but report current and past lifetime cannabis use less than 7 days/week (daily) Exclusion Criteria: * any current medical condition requiring psychoactive/psychotropic medication or medication that would interact with dronabinol, interpretation of fMRI data, and/or interfere with study procedures * current or past allergic or adverse reaction or known sensitivity to cannabinoid-like substances (Dronabinol/Marijuana/Cannabis/THC, cannabinoid oil, sesame oil, gelatin, glycerin, and titanium dioxide.) * current Axis-I Diagnostic Statistical Manual-5 diagnosis (although mild and moderate Cannabis Use Disorder (CUD) and mild and moderate Alcohol Use Disorder (AUD) are allowed) * score \>3 on the Prediction of Alcohol Withdrawal Severity Scale (PAWSS) for individuals with current AUD * lifetime other lifetime Substance Use Disorder (although lifetime severe CUD and lifetime severe AUD are allowed) * currently seeking or engaged in CUD treatment or have desire to cut down or stop cannabis use. * in recovery or enrolled in treatment for any substance (including cannabis and alcohol) * lifetime psychosis, mania, Attention-Deficit/Hyperactivity Disorder, Obsessive-Compulsive disorder, Feeding and Eating disorder, or Post-Traumatic Stress Disorder * score \>7 on the Hamilton Depression Rating Scale or score \>7 on the Hamilton Anxiety Rating Scale * less than a high school education * lack of fluency in English * night shift work * currently pregnant confirmed by urine pregnancy test or planning pregnancy or lactating (women) * unwilling/unable to sign informed consent document * inability to tolerate small, enclosed spaces without anxiety (e.g. claustrophobia), as determined by self-report * left-handed * presence of ferrous-containing metals within the body (e.g., aneurysm clips, shrapnel/retained particles) * positive UDS for any drug except THC * positive breathalyzer for acute alcohol intoxication * heavy alcohol use (\>4 days week) in the past month * heavy nicotine use (\>20 cigarettes per week) in the past month