Therapeutic plasma exchange is widely performed in patients with autoimmune disease. The exact effects of fresh frozen plasma on coagulation in this group of patients remains unknown. In order to investigate this issue the present study monitors periprocedural coagulation status with the aid of standard coagulation tests and rotational thromboelastometry. Four thromboelastometric tests will be performed: ExTEM, InTEM, FibTEM and ApTEM. The following parameters will be recorded from each test: CT (sec), CFT (sec) and MCF (mm) one hour before and one hour after plasmaechange was performed.
Study Type
OBSERVATIONAL
Enrollment
25
the effects of fresh frozen plasma administered during a plasma exchange therapy on viscoelastic tests
Fundeni Clinical Institute
Bucharest, Romania
change in clotting time - CT (%)
change in CT determined before and after plasmaexchange. A 20% change in parameter value will be considered clinically significant.
Time frame: one hour before compared to one hour after plasmaexchange
change clot formation time - CFT (%)
change in CFT determined before and after plasmaexchange. A 20% change in parameter value will be considered clinically significant.
Time frame: one hour before compared to one hour after plasmaexchange
change maximum clot firmness - MCF (%)
change in MCF determined before and after plasmaexchange. A 20% change in parameter value will be considered clinically significant.
Time frame: one hour before compared to one hour after plasmaexchange
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