A Phase IIa Clinical Trial on TSG-01 in the Treatment of Chronic Heart Failure in Patients With Coronary Heart Disease.

Inclusion Criteria: * Age: 40 to 75 years. * Have chronic heart failure(CHF) due to ischemic causes and defined as NYHA classification of III. * Left ventricular ejection fraction (LVEF) of ≤45% and ≥25% as determined by improved biplane Simpson method * NT-proBNP≥450pg/ml * Be on a stable regime of standardized therapy for CHF at least 2 weeks prior to receiving study medication and are respected to remain on a stable regime throughout the duration of the trial without the need to receive intravenously vasoactive agents or/and diuretics. Standardized therapy includes ACEI/ARB, beta-blocker, aldosterone receptor antagonist, diuretic, digitalis. * Is able to understand the trial and provide informed consent. Exclusion Criteria: * Has hypertensive cardiopathy, pulmonary heart disease, congenital heart disease, moderate to severe pulmonary hypertension (pulmonary artery pressure ≥ 40mmHg), moderate to severe cardiac valve stenosis or insufficiency, any type of cardiomyopathy(hypertrophic, restrictive or dilated cardiomyopathy); moderate to severe pericardial effusion, constrictive pericarditis, and heart failure caused by arrhythmia. * Has noncardiogenic heart failure caused by diseases in kidney, lung, liver, or by rheumatic immune disorders, severe infection and chemical factors (chemotherapy, alcohol, etc.). * Has active tuberculosis or systemic lupus erythematosus (SLE) * Had acute myocardial infarction, biventricular pacemaker implantation for cardiac resynchronization, cardiothoracic surgery or was complicated with acute coronary syndrome, pulmonary embolism and acute cerebrovascular disease within 3 months prior to receiving study medication. * Had symptomatic ventricular tachycardia or pleomorphic ventricular tachycardia, cardiogenic shock (CGS), a progressive exacerbation of unstable angina, uncontrolled malignant arrhythmia, second degree sinoatrial or AV block Mobitz Type II or above without pacemaker implantation, QTc\>550 ms and heart rate \<50 bmp. Had uncontrolled hypertension, systolic blood pressure≥180/mmHg and/or diastolic blood pressure≥110mmHg, or hypotension with systolic blood pressure\<90mmHg and/or diastolic blood pressure\<60mmHg. * Had coronary revascularization procedure (percutaneous or surgical) within 12 weeks prior to receiving study medication or be expected to have coronary revascularization or left ventricular remodeling operation in next 12 weeks. * Has hepatic abnormality defined as ALT≥1.5 times the upper limit of normal, or has impaired renal function with Cr≥1.5 times the upper limit of normal. Has severe anemia (Hb\<70g/L), pheochromocytoma, hematopathy, gastrointestinal bleeding (consecutive fecal occult blood tests positive, except bleeding caused by hemorrhoids or other anal diseases). * Has a body weight\>200kg. * The subject has the need for mechanical ventilation, or has a history of a stroke or any malignancy within 4 weeks prior to receiving study medication. * Has psychosis with poor control, or is a drug addict who has not been detoxified. * Allergic to the study drug. * Has participated in any clinical trial involving experimental therapy 3 months prior to screening. * If female, being pregnant or lactating, or plan to get pregnant in next 3 months. * Has a survival time less than 3 months according to the investigator's judgement. * Subject who are taking Entresto (Sacubitril Valsartan Sodium Tablets) medication. * Unable to complete the study or comply with the requirements of the study (for management or other reasons) according to the investigator's judgement.