Sarcopenia, Fall and Osteoporosis in Chronic Kidney Disease

Herlev Hospital140 enrolled

Overview

This study is a cross-sectional study that wishes to investigate whether there is an increased incidence of sarcopenia in patients with chronic kidney disease compared to the Danish background population. A possible association between sarcopenia and fall, as well as the incidence of osteoporosis in patients with chronic kidney disease will also be described.

Sarcopenia is a condition diagnosed from different clinical findings such as low muscle mass, low muscle strength and possibly also poor physical performance. In the general population, the risk of fall and bone fracture increases, when sarcopenia is also present. Sarcopenia is known to occur in patients with chronic kidney disease, but whether, and if so, how this differs from the incidence in patients without kidney disease has not previously been described. Patients with chronic kidney disease have a 3 times higher risk of bone fracture compared to the Danish background population, and they also have an increased risk of falls. The association between sarcopenia, risk of falls and osteoporosis in patients with kidney disease is until now sparsely described, and because of this, the investigators want to explore this further in this cross-sectional study.

Study Type

OBSERVATIONAL

Enrollment

140

Conditions

Sarcopenia Chronic Kidney Diseases Osteoporosis

Interventions

DXADIAGNOSTIC_TEST

Each participant will undergo one DXA scan

Muscle strength and function assessmentOTHER

Each patient will have their muscle strength and function assessed with the measurements of handgrip strength, 10 m gait speed and a 30 s sit-to-stand test. They will also fill out a questionnaire assessing Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls (SARC-F questionnaire).

Blood samplesOTHER

Each patient will undergo a physical examination and also deliver blood samples.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 120 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥20 years * Chronic kidney disease stage 4-5 not on dialysis (nonD) (corresponding to an estimated glomerular filtration rate (eGFR) ≤30 ml/min based on Kidney Disease Improving Global Outcomes (KDIGO) definition and not on dialysis) Exclusion Criteria: * Kidney transplanted * Immobilized/hospitalized for more than 1 week within the last 6 weeks * Active treatment with growth hormone or sex hormone * Known muscle disease * The lack of ability to speak or understand Danish * The lack of ability to give an informed consent * The lack of ability to participate in a clinical study based on the assessment by the local investigator

Locations (2)

Herlev and Gentofte Hospital, Herlev Hospital

Herlev, Denmark

RECRUITING

Odense University Hospital

Odense, Denmark

NOT_YET_RECRUITING

Outcomes

Primary Outcomes

Difference in appendicular lean body mass

Difference in appendicular lean body mass between patients with chronic kidney disease and a healthy control group examined in a previous study