The Diagnostic Value of Autoimmune Antibody Detection in Newly Onset and Chronic Epilepsy

Xijing Hospital130 enrolled

Overview

multi-central and prospectively study the diagnostic value of autoimmune antibody detection in new and chronic epilepsy, and provide reference for clinical practice

multi-centrally recruit patients with newly onset or chronic epilepsy and hoping to find whether there exist an autoimmune cause. whether the patients receive immune therapy or not will depend on the type and titter of the autoimmune antibody as well as the severity of the symptom. At 3 and 6 months later, all patients will be followed-up, and the positive autoimmune antibody will be redetected. the clinical manifest, clinical data, medication and treatment outcome will be recorded and analyzed, to study the diagnostic value of autoimmune antibody detection in new and chronic epilepsy

Study Type

OBSERVATIONAL

Enrollment

130

Conditions

Epilepsy

Interventions

OTHER

There was no intervention in this observational study

Eligibility

Sex: ALLMin age: 16 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with epilepsy according to the diagnostic criteria of International League Against Epilepsy (ILAE) 2017 * Age from 16 to 70 years old * The etiology of patients with epilepsy is unknown * The patient or guardian signs an informed consent and can cooperate with the inspection and follow-up for six months Exclusion Criteria: * Patients with hereditary, infectious, and metabolic epilepsy * The investigation and follow-up cannot be completed due to vision, hearing, language expression, disturbance of consciousness, and impaired understanding, and the guardian cannot replace the completed * Patients with other progressive or systemic diseases

Outcomes

Primary Outcomes

change of the seizure frequency

Seizure frequency are described as no seizures, less than one per month, monthly, weekly, and daily. the change of seizure frequency include 'increased', 'decreased', and 'no change' compared to the frequency before they were enrolled

Time frame: at six months after the patients being enrolled

change of the autoimmune antigen

autoimmune antigen in the serum of patients was described as positive and negative. the change of the autoimmune antigen include 'turn negative' and 'still positive' compared to the first detection.

Time frame: at six months after the patients being enrolled

Data from ClinicalTrials.gov

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