Most patients with glioblastoma have impaired cognitive function, autonomy, and quality of life. This clinical situation, combined with a limited life expectancy, makes the preservation of quality of life a major objective, in a supportive environment that respects family integration. This is especially true since there is an established relationship between health-related quality of life, as measured by questionnaires. In this context, and despite the lack of impact on overall survival, improving quality of life becomes a priority objective in recent Phase III trials. The feasibility of introducing early accompaniment in GBM should be assessed in the diagnostic and therapeutic announcement environment. In order to measure the expected impact as favorable in the patient and his family, a broad survey of the classic domains of quality of life and more specifically dedicated to neurological symptomatology.
glioblastomas are the most common primary malignant tumours of the central nervous system.They represent about 2000 new cases per year in France. Despite active treatments including surgery, radiotherapy and chemotherapy, patient survival is limited without possible cure. Most patients with glioblastoma have impaired cognitive function, autonomy, and quality of life. Exploration of verbal memory in these patients shows that its deterioration is correlated with a more unfavourable prognosis, after adjustment with other usual prognostic factors. This clinical situation, combined with a limited life expectancy, makes the preservation of quality of life a major objective, in a supportive environment that respects family integration. This is especially true since there is an established relationship between health-related quality of life, as measured by questionnaires. The feasibility of introducing early accompaniment in GBM should be assessed in the diagnostic and therapeutic announcement environment. In order to measure the expected impact as favorable in the patient and his family, a broad survey of the classic domains of quality of life and more specifically dedicated to neurological symptomatology.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
35
visit with supportiv unit and neuropsychologue every 3 months
ICM Val d'Aurelle
Montpellier, France
Assess the feasibility in terms of compliance with early medical care in glioblastoma patients by palliative care unit.
Compliance is defined as the proportion of patients attending three palliative care unit visits (Ve1, Ve2 and Ve3).
Time frame: from date of inclusion visit until an average of 3 months
The recruitment rate (proportion of patients giving consent to participate in the study among eligible patients during screening)
Participation rate, defined as the proportion of patients who accepted inclusion in the study among all screened patients. Investigator expect an 80% participation rate in this study
Time frame: at the inclusion visit
Proportion of patients completing all quality of life assessments (QLQ-C30 (Quality Life Questionnaire) at palliative care unit visits (Ve1, Ve2 and Ve3)
The proportion of palliative care unit consultations not carried out due to impossibility for the palliative care unit
Time frame: from date of inclusion visit until an average of 3 months
Proportion of patients completing all BN20 assessments (Brain Cancer Module) at palliative care unit visits (Ve1, Ve2 and Ve3)
The proportion of palliative care unit consultations not carried out due to impossibility for the palliative care unit
Time frame: from date of inclusion visit until an average of 3 months
Proportion of patients completing all anxiety assessments (HADS, Hospital Anxiety and Depression Scale) at palliative care unit visits (Ve1, Ve2 and Ve3)
The proportion of palliative care unit consultations not carried out due to impossibility for the palliative care unit
Time frame: from date of inclusion visit until an average of 3 months
Changes over time in patients' quality of life
Score of questionnaire (QLQ-C30 (Quality Life Questionnaire)
Time frame: from date of inclusion visit until an average of 3 months
Changes over time in patients' quality of life
Score of questionnaire BN20 (Brain Cancer Module)
Time frame: from date of inclusion visit until an average of 3 months
The evolution over time of anxiety and depressive affects in patients
score of HADS questionnaire (Hospital Anxiety and Depression Scale). \<9 no significant, between 10 and12 limit and \> 13 significant
Time frame: from date of inclusion visit until an average of 3 months
The evolution over time of neurocognitive performance in patients and the delay before neurocognitive degradation (Mattis DRS scale);
Neurocognitive performance of patients assessed by total score and scores at sub-scales of attention, initiation, conceptualization, construction and memory at the Mattis DRS scale
Time frame: from date of inclusion visit until an average of 3 months
Rate of patients who have written advance directives since the diagnostic announcement;
The percentage of patients for whom advance directives have been written and documented in the medical record,
Time frame: From date of inclusion until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months
Rate of patients who have designated a support person since the diagnostic announcement
the percentage of patients for whom the support person has been designated
Time frame: From date of inclusion until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months
proportion of patients receiving specific medical oncology treatment in their last month of life
Percentage of patients receiving specific oncology treatment in the month prior to death
Time frame: From date of inclusion until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months
Overall survival
defined as the delay between the date of inclusion and the date of death (any cause) or the date of last update
Time frame: From date of inclusion until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months
The proportion of patients diagnosed with glioblastoma that are available for this medical care
Percentage of patients diagnosed with glioblastoma not care at the center during the inclusion period will be reported, as well as the reasons for not cared at the ICM center
Time frame: at the inclusion visit
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