A study of the relation between genetic biomarkers and child language development in Taiwan.
The interaction between gene and environment (G×E) can be a very complicated process that influences child development. As a pilot study of child development biomarkers, this study investigates genes related to child language development and language disorder.
Study Type
OBSERVATIONAL
Enrollment
596
Chang Gung Memorial Hospital
Taoyuan, Taiwan
RECRUITINGScores of cognitive function 1
Bayley Scales of Infant and Toddler Development (Scores from 0 to 140, higher scores mean a better outcome.)
Time frame: baseline
Scores of cognitive function (2 y/o to 6 y/o)
Wechsler Preschool and Primary Scale of Intelligence (Scores from 0 to 200, higher scores mean a better outcome.)
Time frame: baseline
Scores of cognitive function (6 y/o to 16 y/o)
Wechsler Intelligence Scale for Children (Scores from 0 to 200, higher scores mean a better outcome.)
Time frame: baseline
Scores of cognitive function 3
Test of Nonverbal Intelligence-Fourth Edition (Scores from 0 to 60, higher scores mean a better outcome.)
Time frame: baseline
Scores of language function 1
Peabody Picture Vocabulary Test-Revised (Scores from 0 to 124, higher scores mean a better outcome.)
Time frame: baseline
Scores of language function 2
Preschool Language Impaired Scale(PLS)/Language Impaired Scale(LS) (PLS: Scores from 0 to 65, higher scores mean a better outcome. LS: Scores from 0 to 73, higher scores mean a better outcome.)
Time frame: baseline
Scores of general development
Comprehensive Developmental Inventory for Infants and Toddlers (Higher scores mean a better outcome.)
Time frame: baseline
Gene test 1
Microarray (Use Axiom Genome-Wide TWB 2.0 Array Plate (TWB 2.0) to analyze SNPs of disease-related biomarkers.)
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Time frame: baseline
Gene test 2
Whole-Exome Sequencing (Use Burrows-Wheeler Aligner (BWA) 85, Samtools86, Picard, Genome Analysis Toolkit (GATK) to screen out the variant discovery and genotyping.)
Time frame: baseline
Scores of participation(2-5 y/o)
Assessment of Preschool Children's Participation (Scores from 0 to 45, higher scores mean a better outcome.)
Time frame: baseline
Scores of participation(>6 y/o)
Children Assessment of Participation and Enjoyment and Preferences for Activity of Children (Higher scores mean a better outcome.)
Time frame: baseline
Scores of activities
Functional Independence Measure for Children (Scores from 18 to 126, higher scores mean a better outcome.)
Time frame: baseline
Scores of quality of life
Pediatric Quality of Life Inventory TM (Scores from 0 to 102, higher scores mean a better outcome.)
Time frame: baseline