Indication for hysteroscopic guided biopsy compared to blind biopsy have been little evaluated. However, this kind of biopsy is usually performed in many centre. They allow exploration of uterine cavity but also to perform guided biopsies on the most suspicious area. However, with 5Fr forceps, biopsy are often too small to conclude.
Blind biopsies using Novak or Cormier cannula had limits. Demirkiran et al conclude on 673 women that histology was similar between biopsies and hysterectomy in only 67% of cases. Others studies conclude thatit is difficult to conclude about focal disease with blind biopsies. A study compared blind biopsies to biopsy performed under hysteroscopic guidance in women using Tamoxifene and conclude that guided biopsies were more specific (80% versus 68.9%) and a better positive predictive value (68.9% versus 43.7%) for all kind of endometrial pathologies
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
146
Endometrial sampling with 2 different forceps
AP-HP, Bicêtre Hospital
Le Kremlin-Bicêtre, France
To evaluate ability to give a pathologic conclusion after 5Fr and 7Fr forceps biopsies
Evaluated by the number of cases on witch the biopsy allowed to conclude
Time frame: During the pathologist's analysis
To compare histologic conclusions after 5 and 7Fr biopsies
Evaluated by Importance of collapse artifacts
Time frame: During the pathologist's analysis
To compare rate of ability to obtain pathologic conclusion on the sample after 5Fr and 7Fr forceps in endometrial carcinoma
The number of endometrial malignancies diagnosed histologically with either forceps
Time frame: During the pathologist's analysis
To evaluate the rate of hysteroscopic failure due to cervical stenosis
The number of cases where hysteroscopy was not possible
Time frame: During the pathologist's analysis
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