A Study of CIN-107 in Adults With Treatment-Resistant Hypertension (rHTN)

Inclusion Criteria: * Is on a stable regimen of ≥ 3 antihypertensive agents (one of which is a diuretic) for at least 4 weeks prior to randomization; * Be at least 70% compliant to their anti-hypertensive medication regimen; * Has a seated BP ≥ 130/80 mmHg; * Agrees to comply with the contraception and reproduction restrictions of the study; and * Able to understand and willing to comply with all study visits, procedures, restrictions, and provide written informed consent according to institutional and regulatory guidelines. Exclusion Criteria: * Has a seated SBP ≥ 180 mmHg or DBP ≥ 110 mmHg; * Has a body mass index (BMI) \> 40 kg/m2; * Has an upper arm circumference \< 7 or \> 17 inches; * Has been on night shifts at any time during the 4 weeks before Screening; * Is using a beta blocker for any primary indication other than systemic hypertension (eg, migraine headache); * Is not willing or not able to discontinue an MRA or a potassium sparing diuretic as part of an existing antihypertensive regimen; * Is not willing or not able to discontinue taking a potassium supplement; * Has documented estimated glomerular filtration rate (eGFR) \< 45 mL/min/1.73m2 * Has known and documented New York Heart Association stage III or IV chronic heart failure * Has had a stroke, transient ischemic attack, hypertensive encephalopathy, acute coronary syndrome, or hospitalization for heart failure within 6 months before Screening; * Has known current severe left ventricular outflow obstruction, such as obstructive hypertrophic cardiomyopathy and/or severe aortic valvular disease diagnosed from a prior echocardiogram; * Major cardiac surgery (eg, CABG, valve replacement), peripheral arterial bypass surgery, or PCI within 6 months before Screening; * Has chronic permanent atrial fibrillation; * Has uncontrolled diabetes with glycosylated hemoglobin \> 9.5% at Screening; * Has planned dialysis or kidney transplant during the course of this study; * Potassium \< 3.5 mEq/L; * Potassium \> 5.0 mEq/L; * Is positive for HIV antibody, hepatitis C virus RNA, or hepatitis B surface antigen; * Has typical consumption of ≥14 alcoholic drinks weekly.