The induction dose of propofol is generally determined based on patients' characteristics, underlying disease, general condition, and also by clinician's experiences. However, It is difficult to anticipate and objectively calculate an adequate dose of propofol for every patient considering the variability of an individual's response to propofol. If there is a specific pattern in EEG prior to induction of anesthesia that can provide information about the patient's susceptibility to propofol, every induction may be performed far more smoothly with a precisely optimized dose of propofol for each patient. The study is to find a relationship between the pre-induction EEG pattern of adult patients and their sensitivity to propofol.
Study Type
OBSERVATIONAL
Enrollment
70
The dose of propofol required for loss of consciousness and the total induction dose of propofol will be recorded for every patients.
The processed EEG spectrogram and indices, such as patient status index, 95% spectral edge frequency, and suppression ratio, will be obtained from Sedline monitoring device. The raw pre-induction EEG will be extracted from Sedline at the end of induction and it will be analyzed by an external software to calculate the mean frequency, frequency band power and its distribution.
Seoul National University Hospital
Seoul, South Korea
Absolute and Relative power in distinct frequency (% δ: 1-4 Hz, % θ: 5-8 Hz, % α: 9-12 Hz, % β: 13-25 Hz)
Relative power in distinct frequency (% δ: 1-4 Hz, % θ: 5-8 Hz, % α: 9-12 Hz, % β: 13-25 Hz)
Time frame: During the induction of anesthesia (up to 15 min)
Processed EEG index (PSI; patient state index)
Processed EEG index (PSI; patient state index)
Time frame: During the induction of anesthesia (up to 15 min)
Mean frequency and 95% spectral edge frequency (Hz)
Mean frequency and 95% spectral edge frequency (Hz)
Time frame: During the induction of anesthesia (up to 15 min)
Burst suppression ratio (%)
Burst suppression ratio (%)
Time frame: During the induction of anesthesia (up to 15 min)
The effect-site concentrations of propofol at loss of consciousness (μg/ml)
The effect-site concentrations of propofol at loss of consciousness (μg/ml)
Time frame: During the induction of anesthesia (up to 15 min)
The dose of propofol required for loss of consciousness (mg)
The dose of propofol required for loss of consciousness (mg)
Time frame: During the induction of anesthesia (up to 15 min)
Total amount of propofol used (mg)
Total amount of propofol used (mg)
Time frame: During the induction of anesthesia (up to 15 min)
Time to loss of consciousness (second)
Time to loss of consciousness (second) after the start of induction
Time frame: During the induction of anesthesia (up to 15 min)
Vital sign - blood pressure
Check blood pressure (mmHg)
Time frame: During the induction of anesthesia (up to 15 min)
Vital sign - heart rate
Check heart rate (beats per minute)
Time frame: During the induction of anesthesia (up to 15 min)
Administration of vasopressors (ephedrine, phenylephrine, epinephrine, etc)
Administration of vasopressors (ephedrine (mg), phenylephrine (mcg), epinephrine (mcg), etc)
Time frame: During the induction of anesthesia (up to 15 min)
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