Hepatorenal syndrome is a functional renal impairment occurring in cirrhotic patients . It develops secondary to splanchnic arterial vasodilatation which decreases the effective blood volume, activate the renin-angiotensin-aldosterone system, and stimulate of sympathetic nervous system.This study aims to compare the efficacy of nor-epinephrine versus midodrine/ octreotide, together with intravenous albumin on renal functions of patients with hepatorenal acute kidney injury.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
91
oral midodrine plus octreotide as subcutaneous injection
Intravenous infusion norepinephrine
The National Hepatology and Tropical Research medicine institute
Cairo, Egypt
Full response
the proportion of patients achieved full response defined as return of serum creatinine to a value within 0.3 mg/dl of the baseline value
Time frame: 10 days
Partial response
defined as a regression of at least one acute kidney injury stage with a fall in the serum creatinine value to ≥0.3 mg/dl above the baseline serum creatinine value
Time frame: 10 days
Reversal
Incidence of HRS reversal defined as at least one serum creatinine value of ≤ 1.5 mg/dl while on treatment.
Time frame: 10 days
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