Type I Interferon Alfa-2a in Postmastectomy Breast Reconstruction

Inclusion Criteria: 1. Signed the informed consent. 2. Female aged between 18 and 70 years. 3. Pathologically diagnosed operable breast cancer. 4. WHO Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. 5. Newly diagnosed breast cancer. 6. The important organ functions meet the following criteria: * WBC \>=3.0 x 10\^9/L; Neutrophilic granulocytes \>=1.5×10\^9/L; Platelet \>=100 x 10\^9/L; Hb \>=9 g/dL; * Total bilirubin no more than 1.5 times the normal upper limit (ULN); AST and ALT no more than 1.5 times ULN; AKP no more than 2.5 times ULN; * Serum creatinine no more than 1.5 times ULN or Clearance rate of creatinine \>= 60ml/min; * Thyroid stimulating hormone (TSH) \<= ULN (T3, T4 levels need to be detected simultaneously if abnormalities, the patient can be included if T3, T4 levels is normal); * LVEF basement \>= 50%. Exclusion Criteria: 1. Evidence of distant metastasis. 2. Any contraindication of nipple-areolar complex (NAC) saving mastectomy (NSM): * Intraoperative biopsy revealed carcinoma invasion of NAC. * Paget's disease of breast. * Tumor distant from NAC less than 1 cm. 3. Any invasive malignancy diagnosed within previous 5 years (other than successfully treated cervical carcinoma in situ, skin basal cell carcinoma or cutaneous squamous cell carcinoma). 4. At least 4 months since prior interferon therapy. 5. At least 3 weeks since prior major surgery requiring general anesthesia. 6. At least 3 weeks since prior radiotherapy or chemotherapy. 7. Hypersensitivity to interferon or other components: urticaria, angioedema, bronchial stenosis, anaphylaxis, or Stevens-Johnson syndrome. 8. Prior organ allograft. 9. Use of an unlicensed or other investigational drug within 4 weeks. 10. Any severe comorbidities, inability to give informed consent or unavailability for follow-up, including but not limited to any of the following: * Heart failure above NYHA class 2 level; high-risk uncontrollable arrhythmia; unstable angina pectoris; myocardial infarction within 1 intervention. * Chronic obstructive pulmonary disease requires treatment. * Chronic liver disease (cirrhosis, chronic active hepatitis, etc.). * Cerebrovascular accident occurred within 6 months. * Severe epilepsy or central nervous system diseases. * Hypertension which cannot be well controlled by antihypertensive drugs. * Abnormal coagulation, bleeding tendency, or receiving thrombolysis or anticoagulant therapy. * Chronic renal insufficiency. * Active infection. * Psychiatric disability, etc. 11. Pregnant or lactating women.