CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease in Subjects Who Completed CYS-004

Inclusion Criteria: * Have completed the clinical trial CYS-004 and habe been compliant with trial procedures * Signed ICF (Informed Consent Form) * Subject-reported history of DED in both eyes * Ability and willingness to follow instructions, including participation in all study assessments and visits Exclusion Criteria: * Early termination of CYS-004 * Clinically significant slit-lamp findings or ocular conditions that require prescriptive medical treatment and/or in the opinion of the investigator may interfere with trial parameters * Have a history of herpetic keratitis; * Have an ocular or periocular malignancy; * Be unwilling to avoid wearing contact lenses during the trial; * Have any planned ocular or eyelid surgeries during the trial period * Be a woman who is pregnant, nursing or planning a pregnancy * Unwillingness to submit a urine pregnancy test at all onsite visits if of childbearing potential * Women of childbearing potential not using an acceptable means of contraception * Presence of known allergy and/or sensitivity to the study drug or its components * Be currently using an investigational drug or device or have used an investigational drug or device within 60 days before Visit 1 other than for CYS-004 * Have a condition or be in a situation (eg language barrier) which the investigator feels may put the subject at significant risk,may confound the trial results, or may interfere with the subject's participation in the trial significantly