Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients infected with COVID-19.
Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients with COVID-19. Patients admitted to the intensive care unit, with COVID-19 are examined with echocardiography for assessment of left and right ventricular dysfunction within 72 hours from admission and repeated after four to seven days. Cardiac dysfunction was defined as having either left ventricular (LV) dysfunction, defined as having an ejection fraction \<50% and/or regional hypokinesia, or right ventricular (RV) dysfunction, defined as having a tricuspid annular plane excursion (TAPSE) \<17mm or a moderate/severe RV dysfunction assessed visually. The cardiac biomarkers troponin and NTproBNP and clinical data are recorded at time of each echo. Mortality status is recorded at 30 days.
Study Type
OBSERVATIONAL
Enrollment
132
Echocardiography for assessment of cardiac function
Södersjukhuset
Stockholm, Region Stockholm, Sweden
Sahlgrenska University Hospital/Mölndal
Gothenburg, Västra Götaland County, Sweden
Sahlgrenska University Hospital/Östra
Gothenburg, Västra Götaland County, Sweden
Sahlgrenska University Hospital
Gothenburg, Västra Götaland County, Sweden
Mortality
All cause death in patients with vs without cardiac dysfunction
Time frame: 30 days
Left ventricular dysfunction
Prevalence of left ventricular dysfunction
Time frame: Within 72 hours from admission
Right ventricular dysfunction
Prevalence of right ventricular dysfunction
Time frame: Within 72 hours from admission
Risk-factors
Clinical variables associated with risk of having cardiac dysfunction
Time frame: Within 72 hours from admission
Cardiac biomarkers
Levels of cardiac biomarkers in patients with vs without cardiac dysfunction
Time frame: Within 72 hours from admission
Left ventricular dysfunction
Prevalence of left ventricular dysfunction
Time frame: During ICU-stay
Right ventricular dysfunction
Prevalence of right ventricular dysfunction
Time frame: During ICU-stay
Risk-factors
Clinical variables associated with risk of having cardiac dysfunction
Time frame: During ICU-stay
Cardiac biomarkers
Levels of cardiac biomarkers in patients with vs without cardiac dysfunction
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North Älvsborg County Hospital
Trollhättan, Västra Götalandsregionen, Sweden
Time frame: During ICU-stay