The Utility of Thromboelastography in Traumatic Brain Injury

Shanghai 6th People's Hospital500 enrolled

Overview

Hemocoagulation disorder is recognized to have crucial effects on hemorrhagic or ischemic diseases. Coagulation-related damages secondary to traumatic brain injury are common and severe secondary insults of head trauma and often leads to a poor prognosis. In this study, we sought to assess if posttraumatic hemocoagulation disorders determined using thromboelastography are associated with coagulation-related damages secondary to traumatic brain injury, and evaluate their influence on outcome among patients with head trauma. Based on above results, prediction models or risk scoring systems will be further developed and validated to predict coagulation-related damages secondary to traumatic brain injury.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Traumatic Brain Injury Coagulation Disorder

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who are delivered to hospital within 24 hours after head trauma * Patients whose abbreviated injury score (AIS) for other body regions is 3 or less are considered to be isolated traumatic brain injury Exclusion Criteria: * Patients with existing prior neurological disease * Patients with known coagulation disorders * Patients on anticoagulants and medications known to affect coagulation function within 30 days before trauma * Patients receiving blood components prior to blood draw * Patients who deteriorate and die before determining whether coagulation- related damage exists

Outcomes

Primary Outcomes

Glasgow Outcome Scale scores

Glasgow Outcome Scale 1 = death; Glasgow Outcome Scale 2 = vegetative state; Glasgow Outcome Scale 3 = severe neurological deficit; Glasgow Outcome Scale 4 = mild neurological deficit and Glasgow Outcome Scale 5 = premorbid level of functioning or completely recovery. Unfavorable outcome is defined as a Glasgow Outcome Scale score of ≤ 3, and favorable outcome is defined as a Glasgow Outcome Scale score of \> 3.

Time frame: Six months