Natural History of Patients With Inherited Retinal Diseases Due to Mutations in RPE65 Gene

Inclusion Criteria: * Must be willing to adhere to protocol as evidenced by written informed consent or parental permission and subject assent. * Subjects diagnosed with Retinitis Pigmentosa or Leber Congenital Amaurosis. * Molecular diagnosis showing mutations (homozygotes or compound heterozygotes) in RPE65 gene. * Age three years old or older. * Minimum of two office / clinic visits encounters with ophthalmic assessment that span a follow-up period of at least 1 year with the last visit occurring within the last six months (before signature of informed consent and of study start). Exclusion Criteria: * Unable or unwilling to meet requirements of the study. * Participation in a clinical study with an investigational drug during the retrospective study time period (i.e., from 01/01/1990 to study start date).