The purpose of this study is to investigate the pharmacokinetics and pharmacodynamics of dopamine which is used as treatment of hypotension in neonate and preterm infant.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Dopamine treatment
Seoul National University Children's Hospital
Seoul, South Korea
Steady state concentration of dopamine (Css) at 2mcg/kg/min
dopamine drug level in blood
Time frame: After continuous infusion for more than 30 minutes at 2mcg/kg/min
Steady state concentration of dopamine (Css) at 5mcg/kg/min
dopamine drug level in blood
Time frame: After continuous infusion for more than 30 minutes at 5mcg/kg/min
Steady state concentration of dopamine (Css) at 10mcg/kg/min
dopamine drug level in blood
Time frame: After continuous infusion for more than 30 minutes at 10mcg/kg/min
Steady state concentration of dopamine (Css) at 15mcg/kg/min
dopamine drug level in blood
Time frame: After continuous infusion for more than 30 minutes at 15mcg/kg/min
Steady state concentration of dopamine (Css) at 20mcg/kg/min
dopamine drug level in blood
Time frame: After continuous infusion for more than 30 minutes at 20mcg/kg/min
Blood pressure in mmHg at 2mcg/kg/min
Systolic, diastolic and mean blood pressure in mmHg
Time frame: After continuous infusion for more than 30 minutes at 2mcg/kg/min
Blood pressure in mmHg at 5mcg/kg/min
Systolic, diastolic and mean blood pressure in mmHg
Time frame: After continuous infusion for more than 30 minutes at 5mcg/kg/min
Blood pressure in mmHg at 10mcg/kg/min
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Systolic, diastolic and mean blood pressure in mmHg
Time frame: After continuous infusion for more than 30 minutes at 10mcg/kg/min
Blood pressure in mmHg at 10mcg/kg/min
Systolic, diastolic and mean blood pressure in mmHg
Time frame: After continuous infusion for more than 30 minutes at 20mcg/kg/min
Heart rate
Time frame: After continuous infusion for more than 30 minutes at 2mcg/kg/min
Heart rate
Time frame: After continuous infusion for more than 30 minutes at 5mcg/kg/min
Heart rate
Time frame: After continuous infusion for more than 30 minutes at 10mcg/kg/min
Heart rate
Time frame: After continuous infusion for more than 30 minutes at 15mcg/kg/min
Heart rate
Time frame: After continuous infusion for more than 30 minutes at 20mcg/kg/min
Ejection fraction from Echocardiography
Time frame: After continuous infusion for more than 30 minutes at 2mcg/kg/min
Ejection fraction from Echocardiography
Time frame: After continuous infusion for more than 30 minutes at 5mcg/kg/min
Ejection fraction from Echocardiography
Time frame: After continuous infusion for more than 30 minutes at 10mcg/kg/min
Ejection fraction from Echocardiography
Time frame: After continuous infusion for more than 30 minutes at 15mcg/kg/min
Ejection fraction from Echocardiography
Time frame: After continuous infusion for more than 30 minutes at 20mcg/kg/min
Fractional shortening from Echocardiography
Time frame: After continuous infusion for more than 30 minutes at 2mcg/kg/min
Fractional shortening from Echocardiography
Time frame: After continuous infusion for more than 30 minutes at 5mcg/kg/min
Fractional shortening from Echocardiography
Time frame: After continuous infusion for more than 30 minutes at 10mcg/kg/min
Fractional shortening from Echocardiography
Time frame: After continuous infusion for more than 30 minutes at 15mcg/kg/min
Fractional shortening from Echocardiography
Time frame: After continuous infusion for more than 30 minutes at 20mcg/kg/min
Tei index from Echocardiography
(Mitral valve closure to opening time(ms)-LV ejection time(ms))/LV ejection time(ms)
Time frame: After continuous infusion for more than 30 minutes at 2mcg/kg/min
Tei index from Echocardiography
(Mitral valve closure to opening time(ms)-LV ejection time(ms))/LV ejection time(ms)
Time frame: After continuous infusion for more than 30 minutes at 5mcg/kg/min
Tei index from Echocardiography
(Mitral valve closure to opening time(ms)-LV ejection time(ms))/LV ejection time(ms)
Time frame: After continuous infusion for more than 30 minutes at 10mcg/kg/min
Tei index from Echocardiography
(Mitral valve closure to opening time(ms)-LV ejection time(ms))/LV ejection time(ms)
Time frame: After continuous infusion for more than 30 minutes at 15mcg/kg/min
Tei index from Echocardiography
(Mitral valve closure to opening time(ms)-LV ejection time(ms))/LV ejection time(ms)
Time frame: After continuous infusion for more than 30 minutes at 20mcg/kg/min
VTI (velocity time integral) from Echocardiography
the area within the spectral curve and indicates how far blood travels during the flow period
Time frame: After continuous infusion for more than 30 minutes at 2mcg/kg/min
VTI (velocity time integral) from Echocardiography
the area within the spectral curve and indicates how far blood travels during the flow period
Time frame: After continuous infusion for more than 30 minutes at 5mcg/kg/min
VTI (velocity time integral) from Echocardiography
the area within the spectral curve and indicates how far blood travels during the flow period
Time frame: After continuous infusion for more than 30 minutes at 10mcg/kg/min
VTI (velocity time integral) from Echocardiography
the area within the spectral curve and indicates how far blood travels during the flow period
Time frame: After continuous infusion for more than 30 minutes at 15mcg/kg/min
VTI (velocity time integral) from Echocardiography
the area within the spectral curve and indicates how far blood travels during the flow period
Time frame: After continuous infusion for more than 30 minutes at 20mcg/kg/min