Acute kidney injury (AKI) is one of the most important factors associated with increased mortality in patients with acute-on-chronic liver failure (AoCLF). Early identification and treatment of this subgroup of patients may improve survival and decrease ICU length of stay. As kidney ischemia is one of the main mechanisms responsible for AKI in AoCLF, an increase in urinary to arterial partial pressure of oxygen may help in the early diagnosis of renal failure. For this arterial and urinary oxygen pressure will be measured at ICU admission, on day 1 and day 3 of ICU stay. Diagnosis of AKI within the first 28 days after ICU admission will be recorded
Study Type
OBSERVATIONAL
Enrollment
200
Popescu Mihai
Bucharest, Romania
AKI
incidence (%) of AKI in patients with AoCLF as defined by Acute Kidney Injury Network guidelines
Time frame: 28 days after ICU admission
arterial to urinary oxygen gradient
mathematical difference in oxygen partial pressure between arterial blood and urine (mmHg) in patients with AKI compared to patients without AKI
Time frame: ICU admission, ICU day 1 and ICU dy 3
mortality
28-day mortality
Time frame: 28-days
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