Gut Microbiome Dysbiosis in Sepsis-induced Coagulopathy

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University60 enrolled

Overview

In the diagnosis and treatment of patients with sepsis, through routine stool testing and dynamic testing of coagulation function, we found that patients often have stools that are not formed, the proportion of main fecal bacteria is imbalanced, the level of blood bacterial toxins rises, and the abnormal coagulation status indicate the gut microbiome dysbiosis may play an important regulatory role in abnormal blood coagulation in patients with sepsis. Therefore, we propose that the gut microbiome dysbiosis is involved in sepsis-induced coagulopathy. This project intends to prospectively observe the changes in gut microbiome dysbiosis and blood coagulation function in patients with sepsis before and after treatment, and explore whether the changes in gut microbiome dysbiosis promote the development of sepsis through coagulation disorders, provide new research perspectives for diagnosis and treatment for sepsis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sepsis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years and ≤85 years * Sign the informed consent form * Expected ICU hospital stay\> 24 hours * △SOFA score ≥2 and confirmed or suspected infection Exclusion Criteria: * Pregnant or breastfeeding women * Estimated survival time \<24 hours * Diagnosis of sepsis time\> 24 hours * The length of ICU stay before diagnosis of sepsis\> 7 days * Sepsis from which the source of infection cannot be determined * Congenital coagulopathy

Locations (1)

Outcomes

Primary Outcomes

Gut Microbiome alterations

Taxonomic alterations,bacterial alpha diversity alterations,beta-diversity alterations of gut microbiome by performing metagenomic sequencing analysis of fecal samples

Time frame: Day 1- Day 14

coagulation disorder tests

Laboratory tests of coagulation disorder,such as PT,APTT,INR,TEG,fibrin degradation products , D-dimers.