This trial will evaluate the safety and efficacy of first time in human engineered T-cell therapies, in participants with advanced tumors.
This study is a master protocol. It has two sub studies registered as 209012 Sub Study 1 (NCT06048705) and 209012 Sub Study 2 (NCT05943990).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
12
GSK3901961 as an IV infusion.
GSK3845097 as an IV infusion.
GSK4427296 as an IV infusion.
GSK Investigational Site
Jacksonville, Florida, United States
GSK Investigational Site
Atlanta, Georgia, United States
Number of Participants Enrolled Across Sub Studies
Number of Participants Randomized across sub studies are presented.
Time frame: Day -7
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Cyclophosphamide will be used as lymphodepleting chemotherapy and will be administered via IV route.
Fludarabine will be used as lymphodepleting chemotherapy and will be administered via IV route.
GSK Investigational Site
Westwood, Kansas, United States
GSK Investigational Site
Lexington, Kentucky, United States
GSK Investigational Site
Baltimore, Maryland, United States
GSK Investigational Site
St Louis, Missouri, United States
GSK Investigational Site
New York, New York, United States
GSK Investigational Site
New York, New York, United States
GSK Investigational Site
Houston, Texas, United States
GSK Investigational Site
Melbourne, Victoria, Australia
...and 7 more locations