Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke With Mild Symptoms

Shanghai East Hospital105 enrolled

Overview

Mechanical thrombectomy(MT) has been recommended in patients with acute large vessel occlusion stroke(LVO) , especially for those with National Institutes of Health Stroke Scale (NIHSS) score ≥6. However, it is still unclear if patients with minor strokes and LVO also benefit from MT.The aim of this study was to evaluate the safety and efficacy of MT for acute LVO and mild symptoms.

This is a prospective cohort study of patients with with mild ischemic stroke (NIHSS Score \<6) and LVO. Patients were divided into 2 groups: MT or medical management.Baseline data and clinical outcomes were compared. A independent clinical outcome was defined as a modified Rankin Scale score of 0 to 2 at 90 days. A excellent clinical outcome was defined as a modified Rankin Scale score of 0 to 1 at 90 days. Symptomatic intracranial hemorrhage(sICH) was the safety outcome.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

105

Conditions

Ischemic Stroke Acute Stroke

Interventions

Mechanical ThrombectomyPROCEDURE

Solitaire stent and manual aspiration thrombectomy were performed as the first-line endovascular treatment

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. acute ischemic stroke within 24 hours of symptom onset presenting cortical symptoms (such as aphasia, somnolence,slow-minded,etc.) or vertigo with bilateral pathological signs; 2. age≥18 years old; 3. the NIHSS score before evaluation of thrombectomy\<6; 4. large artery occlusion including Middle cerebral artery M1, proximal M2 segment, intracranial internal carotid artery and infarct core volume≤50ml and mismatch ratio\>1.8 or basilar artery and posterior cerebral artery P1 occlusion Exclusion Criteria: 1. Patients without prior functional independence (mRS score of \>2) 2. Patients in intervention group with occlusive artery spontaneous recanalization in digital subtraction angiography 3. patients in control group with neurological worsening and received rescue thrombectomy

Locations (1)

Gang Li

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

modified Rankin Scale(mRS) score of 0 to 2

independent outcome at 90 days

Time frame: 90 days

Secondary Outcomes

modified Rankin Scale(mRS) score of 0 to 1

excellent outcome at 90 days

Time frame: 90 days

Data from ClinicalTrials.gov

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