Effects of Low FODMAP Diet on Leaky Gut

Inclusion Criteria: * aged 18-65 years at the time of screening * normal serum studies including serum tissue-transglutaminase antibodies, thyroid stimulating hormone levels, C-reactive protein, complete blood count since the onset of symptoms * normal stool studies including C diff testing, culture, ova and parasites since the onset of symptoms * IBS-SSS score of ≥175 at the end of 7-day screening period Exclusion criteria: * individuals already on a LFD or other dietary restriction such as gluten free diet within the past 6 months * individuals with any known food allergy or insulin-dependent diabetes * known history of celiac disease, inflammatory bowel disease or microscopic colitis * prior small bowel or colonic surgery or cholecystectomy * pregnant patients * antibiotics in the past 3 months * those who regularly use mast cell stabilizers or anti-histaminic or non-steroidal anti-inflammatory agents (NSAIDs) excluding daily baby aspirin or steroids or bile-acid binder.