This study aims to evaluate and compare incidence of post-operative cystoid macular edema (CME) after Descemet Membrane Endothelial Keratoplasty (DMEK), Descemet's Stripping Automated endothelial Keratoplasty (DSEK) and Descemet Stripping Only (DSO).
Patients that are undergoing any of these procedures will be asked if they are willing to have a baseline pre-operative Optical Coherence Tomography (OCT) scan completed within 4 weeks of surgery. Additional OCT scans will be collected during routine follow up care. It is hypothesized that the rates of CME will be lower with DSO compared to DMEK and DSEK.
Study Type
OBSERVATIONAL
Enrollment
4
OCT is an imaging method that uses light waves to create images of the retina.
Wake Forest Health Sciences
Winston-Salem, North Carolina, United States
Incidence of Post-Op CME
The frequency (number of Subjects) of post-operative Cystoid Macular Edema will be evaluated for patients receiving DMEK, DSEK or DSO.
Time frame: 6 weeks post-operative
Incidence of Post-Op CME
The frequency (number of Subjects) of post-operative Cystoid Macular Edema will be evaluated for patients receiving DMEK, DSEK or DSO.
Time frame: 3 months post-operative
Severity of Post-Op CME
The severity of post-operative Cystoid Macular Edema will be evaluated for patients receiving DMEK, DSEK or DSO that experience Cystoid Macular Edema after surgery - measured by net change of Central Foveal Thickness on Optical Coherence Tomography (OCT- is an imaging technique that uses low-coherence light to capture micrometer-resolution, two- and three-dimensional images from within optical scattering media, e.g., biological tissue)
Time frame: 6 weeks post-operative
Severity of Post-Op CME
The severity of post-operative Cystoid Macular Edema will be evaluated for patients receiving DMEK, DSEK or DSO that experience Cystoid Macular Edema after surgery - measured by net change of Central Foveal Thickness on Optical Coherence Tomography (OCT- is an imaging technique that uses low-coherence light to capture micrometer-resolution, two- and three-dimensional images from within optical scattering media, e.g., biological tissue)
Time frame: 3 months post-operative
Graft Detachment
Frequency (number of Subjects) of post-operative graft detachment will be evaluated in patients that receive a corneal endothelial transplant.
Time frame: 6 weeks and 3 months post-operative
Re-bubbling Procedure
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The incidence (number of Subjects) of re-bubbling procedures performed post-operatively will be evaluated.
Time frame: 6 weeks and 3 months post-operative
Infection
The incidence (number of Subjects) of post-operative infection will be evaluated.
Time frame: 6 weeks and 3 month post-operative
Final Visual Acuity
The Snellen Visual Acuity test - This means that the test subject sees the same line of letters at 20 feet that person with normal vision sees at 20 feet. 20/40 vision means that the test subject sees at 20 feet what a person with normal vision sees at 40 feet.
Time frame: 3 months post-operative