Midazolam Versus Dexamethasone as an Adjuvant to Local Anesthetics in the Ultrasound Guided Hydrodissection of Median Nerve for Treatment of Carpal Tunnel Syndrome Patients

Minia University134 enrolled

Overview

midazolam and dexamethasone both can counteract chronic pain. either via GABA mimetic action or via anti prostaglandins

Entrapement syndrome - namely median nerve compression in carpal tunnel syndrome - causes chronic pain that can be refractory to medical treatment . Ultrasound guided hydrodissection is an option for alleviating pain . Recurrence is the main side effect of injection. We try in this research to prevent recurrence rate . Midazolam and dexamethasone both are used in chronic pain . Midazolm act by GABA mimetic action while dexamethasone act by decrease interleukin formation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

134

Conditions

Pain Syndrome

Interventions

DexamethasoneDRUG

Ultrasound guided median nerve hydrodiseection using dexamethasone or midazolam

Midazolam injectionDRUG

intracarpal injection of midazolam and bupivacaine 0.5%

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * numbness or pain in the nerve distribution, nerve conduction studies (NCS) corresponding with AANEM guidelines * Nerve cross sectional area \>12mm2 Exclusion Criteria: * Refusal to participate * History of operation in median nerve.were patient refusal to participate, pain recurrence after previous injection and severe symptoms requiring surgical release, diabetic patients

Locations (1)

Mina Maher Raouf

ALMinya, Egypt, Egypt

Outcomes

Primary Outcomes

comparing efficacy of midazolam against dexmethasone in combination with bupivacaine 0.5%

use of visual analogue score

Time frame: up to 6 months

Secondary Outcomes

Subjective pain assesment

BOSTON questionnaire

Time frame: up to 6 months

complications

neurotoxicity, pain recurrence after injection

Time frame: pain recurrence after 6 months, neurotoxicity immediately after injection

Nerve electrophysiology

sensory nerve conduction , distal motor latency.

Time frame: up to 6 months

nerve sonogram

nerve cross sectional area.

Time frame: up to 6 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.