Presentation, Clinical Course and Patterns of Myocardial Damage Due to Viral Myocarditis

Assiut University18 enrolled

Overview

Presentation, Clinical Course and Patterns of Myocardial Damage due to Viral Myocarditis

1. Determine the pattern of myocarditis in hospitalized patients with acute HF within the last 3 months. 2. Determine the pattern of broad spectrum cardiotropic viruses in patients with acute HF within the last 3 months. These viruses like enteroviruses, adenoviruses and parvo B19 virus, HBV, HCV and Covid 19 virus due to its increased prevelance nowadays.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Viral Myocarditis

Interventions

ELIZA, Extraction of nucleic acid ,Determination of viral genome by using PCR, Quantitative real-time PCR to assess viral load ,Immunohistochemistry analysis of EMB.DIAGNOSTIC_TEST

ELIZA, Extraction of nucleic acid ,Determination of viral genome by using PCR, Quantitative real-time PCR to assess viral load ,Immunohistochemistry analysis of EMB.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: All patients admitted with symptoms , signs and echocardiographic finding suggesting myocarditis within 3 months from start of the symptoms. as acute heart failure, arrhythmias, typical chest pain with ST segment deviation in ECG . dilated cardiomyopathy associated with normal Coronary Angiography, history of upper respiratory tract infection within the last 3 months. Exclusion Criteria: 1. Patients with significant coronary artery disease. 2. Patient with family history suggesting familial DCMP 3. Critically ill patients. 4. Patients who refuse to do coronary angiography . . 5. Patients with severe valvular heart disease. 6. Pregnant women 7. Patients with raised renal chemistry. 8. Echocardiographic finding showing LVEDD more than 6.5cm

Locations (1)

Shery Refaat Asaad

Asyut, Egypt

RECRUITING

Outcomes

Primary Outcomes

Determine the pattern of myocarditis in hospitalized patients with acute HF within the last 3 months

All patients admitted with symptoms , signs and echocardiographic finding suggesting myocarditis within 3 months from start of the symptoms. as acute heart failure, arrhythmias, typical chest pain with ST segment deviation in ECG . dilated cardiomyopathy associated with normal Coronary Angiography, history of upper respiratory tract infection within the last 3 months. All will be investigated for determine the pattern of viral myocarditis in those patients

Time frame: 6 months

Secondary Outcomes

determination of the caustive organism

1\. Determine the pattern of broad spectrum cardiotropic viruses in patients with acute HF within the last 3 months. These viruses like enteroviruses, adenoviruses and parvo B19 virus, HBV, HCV and Covid 19 virus due to its increased prevelance nowadays.

Time frame: 6 months

Central Contacts

Shery Asaad, Resident

CONTACT

01270992244 drshosho31@yahoo.com

Amr yousif, professor

CONTACT

01027355511 amryoussef111@aun.edu.eg

Data from ClinicalTrials.gov

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