Anosmia and / or Ageusia and Early Corticosteroid Use

ClinAmygate300 enrolled

Overview

Time to recover of Anosmia and / or ageusia and early corticosteroid use

In a study of dexamethasone kinetics in two groups of 15 patients with community-acquired pneumonia, one group was treated with dexamethasone 6 mg/day by mouth and the other with 4 mg/day intravenously. The apparent volume of distribution was 1 L/kg in both groups, but the half-life after oral administration was approximately 7 hours, and after intravenous administration 9 hours. The bioavailability of oral dexamethasone was 81% (95% CI = 54-121%). However, the biological half-life of dexamethasone is much longer, of the order of 36-54 h compared with 18-36 h for prednisolone. Time to recover of Anosmia and / or ageusia and early corticosteroid use

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

300

Conditions

Covid19 Anosmia

Interventions

Early-DexamethasoneDRUG

early use of dexamethasone as early as laboratory evidence of high inflammatory markers

Late dexamethazoneDRUG

Use of dexamethasone on deterioration of the cases with increased severity

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Any case with COVID-19 * Age more than or equal to 18 years * Mild to moderate severity Exclusion Criteria: * Diabetes * Any contra-indication for the interventional drug * Mentally disabled cases

Locations (1)

Asalam

Maadi, Cairo Governorate, Egypt

RECRUITING

Outcomes

Primary Outcomes

Time to recovery

Time to recovery from anosmia and / or agusia

Time frame: one to 6 weeks

Central Contacts

Emad R Issak, MD

CONTACT

01272228989 dr.emad.r.h.issak@gmail.com

Data from ClinicalTrials.gov

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