The study aims to demonstrate the relationship between intra-abdominal hypertension (IAH) and abundant microaspirations in mechanically ventilated cirrhotic.
Intra-abdominal pressure monitoring will be performed using intra-vesical pressure every 8 hour in the first 2 days of mechanical ventilation. Micro aspiration is defined by pepsin or amylase positivity in trachea suction. Two groups will be compared : one with IAH , one without IAH.
Study Type
OBSERVATIONAL
Enrollment
226
Hop Claude Huriez Chu Lille
Lille, France
RECRUITINGHop Salengro - Hopital B
Lille, France
RECRUITINGabundant microaspiration
presence of pepsin or alpha amylase at significant level in at least 30% of tracheal aspirates
Time frame: 48 hours after inclusion
Mortality
number of death
Time frame: from ICU admission until day 28
Incidence of ventilator associated pneumonia (VAP)
percentage of patients with VAP
Time frame: from intubation until day 28 or extubation
duration of mechanical ventilation
number of days with mechanical ventilation
Time frame: from intubation until day 28 or extubation
incidence of patients requiring renal replacement therapy
percentage of patients with renal replacement treatment
Time frame: from ICU admission until Day 28 or ICu discharge, whichever came first
incidence of cirrhosis related complications
percentage of patients with cirrhosis related complications
Time frame: from ICU admission until Day 28 or ICU discharge, whichever came first
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