Intraoperative Brain Microdialysis to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection.

N/AEnrolling By InvitationNCT04531722

Mayo Clinic3 enrolled

Overview

This research study will investigate the fluid from the area of the brain that is being removed during clinical epilepsy surgery. The goal is to analyze this fluid for inflammatory markers that can potentially help identify new strategies in the future to control seizures in individuals with epilepsy who fail to respond to currently available drugs.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Epilepsy

Interventions

Intraoperative brain microdialysisPROCEDURE

Our current standard practice is to use a lateral approach through the middle temporal gyrus to place 3 depth electrodes targeting the hippocampus for intraoperative verification of pathological epileptiform activity prior to resection. Our research protocol will add one FDA approved electrode that has a central cannula for insertion of a microdialysis probe.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria * Failure to respond to at least two trials of anti-seizure drugs with different mechanisms of action * Normal MRI Exclusion Criteria * Active immunomodulatory therapy * Autoimmune disorder * Signs or symptoms consistent with comorbid infection * Oncological comorbidity

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Detection of analytes/protein

Presence of protein in the microdialysate

Time frame: Through study completion, up to 5 years

Data from ClinicalTrials.gov

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