The present study is a sub-study of the ENTAiER study. The ENTAiER study is a multicenter, randomized, controlled study to evaluate the efficacy and safety of eurythmy therapy and Tai Chi in comparison to standard care in chronically ill older patients with an increased risk of falling. In addition to the main questions of the ENTAiER study, three additional questions are being investigated at the Hospital Essen-Steele: Proteome and telomere analyses as well as qualitative parameters are recorded and examined. The aim is to compare the changes in proteomes, telomeres and qualitative factors under eurythmy therapy, Tai Chi and standard care in chronically ill older patients with an increased risk of falling.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
A mindfulness-oriented movement therapy
A martial art developed in China, which in recent times is often regarded as a system of movement theory or gymnastics
Treatment process that a clinician should follow for a certain type of patient
Kliniken Essen-Mitte
Essen, Germany
Change in proteomic analysis from baseline to after intervention
A maximum of 500 µL plasma is used for the proteomic studies. The proteins are digested tryptically, a concentration determination is performed by amino acid analysis and the peptide samples are then measured by different mass spectrometric methods (data dependent (DDA) and independent detection (DIA), proteome-wide prediction of peptide tandem mass spectra by deep learning (Prosit), etc.). The results obtained are then verified by Western blot, ELISA and/or a targeted mass spectrometric method (parallel reaction monitoring)
Time frame: Before intervention (week 0) and after intervention (6 months)
Change in telomer analysis from baseline to after intervention
The telomere length is determined from blood samples using quantitative real-time PCR (TaqMan) from genomic DNA.
Time frame: Before intervention (week 0) and after intervention (6 months)
Qualitative parameter
By means of semi-structured interviews of maximum 60 minutes per participant, the effects of the intervention are to be recorded qualitatively.
Time frame: After intervention (6 months)
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