The use of growth hormone in obese cases with COVID-19 may help them to recover earlier.
It is well known that lymphoid organs such the thymus, the spleen and peripheral blood produce growth hormone (GH) and GH receptor is expressed on different subpopulations of lymphocytes. Many in vitro and in animal studies demonstrate an important role of GH in immunoregulation. GH stimulates T and B cells proliferation and immunoglobulin synthesis, enhances the maturation of myeloid progenitor cells and is also able to modulate cytokine response. The use of growth hormone in obese cases with COVID-19 may help them to recover earlier.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Recombinant growth hormone will be used
Saline injection with the same amount
Asalam
Maadi, Cairo Governorate, Egypt
Need for hospitalization
need to be hospitalized due to deterioration
Time frame: one to two weeks
Time to recovery
Time to recovery from symptoms and signs
Time frame: one to four weeks
Percentage of reduction in CRP
Percentage of reduction in CRP
Time frame: one to two weeks
Percentage of reduction in LDH
Percentage of reduction in LDH
Time frame: one to two weeks
Percentage of reduction in Ferritin
Percentage of reduction in Ferritin
Time frame: one to two weeks
Time to recovery from leucopenia
Time to recovery from leucopenia
Time frame: one to two weeks
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