Efficacy and Safety of Dapagliflozin in Children With Proteinuria

Inclusion Criteria: * Age 6 years to 18 years; * Urinary protein excretion \> 0.2g in a 24-hr urine collection; * eGFR≥60 ml/min/1.73m2; * No history of diabetes; * On stable doses of ACE inhibitors or angiotensin receptor blockers (ARBs) for \> 1 month; Exclusion Criteria: * Receiving immunosuppressive therapy within three months prior to enrolment. * Blood pressure less than 5th percentile of the same gender, age, and height - * Leukocyte and/or nitrite positive urinalysis that is untreated; * History of organ transplantation, cancer, liver disease; * Evidence of hepatic disease as determined by any one of the following: ALT or AST values exceeding 3x ULN at the screening visit; * History of noncompliance to medical regimens or unwillingness to comply with the study protocol.