Safety, Tolerability and Renal Effects of APX-115 in Subjects With Type 2 Diabetes and Nephropathy

Inclusion Criteria: * Clinical Diagnosis of type 2 diabetes and nephropathy * First morning void (FMV) UACR between 200 and 3000 mg/g, inclusive * 30 mL/min/1.73m2 ≤ eGFR ≤ 90 mL/min/1.73m2 using CKD-EPI formula at screening * HbA1c ≤ 10% at screening visit * Subject who has been taking unchanged dosage of ACE inhibitor or ARB medication for at least 3 months prior to screening and is not anticipated to change its dosage during the course of the study * Willing to be under dietary management for diabetes Exclusion Criteria: * History of type 1 diabetes mellitus or gestational diabetes * Subject's renal impairment and/or albuminuria is considered to be of origin other than Diabetic Kidney Disease * Subject with uncontrolled blood pressure * Clinically significant abnormal laboratory findings * History of any cardiovascular event within 6 months prior to screening or cardiovascular procedure planned during the clinical trial * Diagnostic or interventional procedure requiring a contrast agent within 4 weeks before the screening visit or planned during the course of the study * Clinically significant ECG abnormalities on a 12-lead ECG at the screening visit or before randomization * Current or history of NYHA class IV heart failure