The treatment before bone marrow transplantantion is initiated by chemotherapy associated or not with radiotherapy, both of which cause various side effects on the patient as symptoms that impair food intake. The nutritional status of the patient is one of the factors related to the success of the transplant, so a complete nutritional assessment before transplantation is necessary in order to identify patients at nutritional risk, nutritional disorders and to perform appropriate and early intervention to promote recovery and / or health maintenance. Will be used for nutritional assessment: arm perimeter, arm muscle area; electrical bioimpedance, phase angle, and Indirect Calorimetry, a standard method of noninvasive nutritional assessment that expresses the nutritional demand and rate of utilization of energy substrates from oxygen consumption and carbon dioxide production through the air inhaled and exhaled by the individual's lungs.
Study Type
OBSERVATIONAL
Enrollment
20
In the pre-transplant, before the conditioning regime, and also on the 10th and 17th post-transplant, the resting energy expenditure was measured by indirect calorimetry.
Escola de Enfermagem - UFMG
Belo Horizonte, Minas Gerais, Brazil
Energy expenditure
The energy expenditure will be analyzed by the volume of oxygen (VO2) consumed, the volume of carbon dioxide (VCO2) produced and the respiratory quotient (VO2 / VCO2). The values analyzed will be the results of the measures of energy expenditure (BMR) before and after the transplant, in calories (Kcal), to verify changes caused by chemotherapy and / or radiation therapy.
Time frame: Up to 3 weeks after protocol termination
Nutritional status of patients
We'll use ASG for this parameter. Patients will have nutritional status classified as malnourished, nourished or overweight, in the periods before and after transplantation to verify changes caused by chemotherapy and / or radiation therapy.
Time frame: Up to 3 weeks after protocol termination
Caloric and protein adequacy
The caloric and protein adequacy will be analyzed by the amount of calorie (kcal / kg / day) and protein (g / kg / day) intake, compared to calorie and protein required before and after transplantation, to verify changes caused by chemotherapy and / or radiation therapy.The caloric and protein adequacy will be presented with g/kg/day (protein) or kcal/kg/day (calories)
Time frame: Up to 3 weeks after protocol termination
Clinical outcomes
Patients will have the following outcomes: * constipation or diarrhea - Bristol stool scale pontuation (7 points scale) * mucositis (grade I-IV) - Dentistry report with grade of mucositis in grade I,II,III or IV * graft versus host disease (grade I-IV) - Medical report with grade of GVHD in grade I, II, III or IV * presence of Cytomegalovirus infection - Blood test Positive or Negative * colonization of Clostridium difficile - Feces Test Positive or Negative * infection by Candida - Laboratory test positive or negative * another diagnosis of infection - Medical report/ Yes or no for presence of this complication * presence of febrile neutropenia - Medical report / Yes or no for presence of this complication * length of hospital stay - number of complete days of hospitalization * death during the hospital stay - number of death during hospitalization
Time frame: Up to 3 weeks after protocol termination
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