The Relationship Between Blood Pressure and Arterial Stiffness in HFpEF Patients With Different Levels of Obesity

Chongqing Medical University200 enrolled

Overview

Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between blood pressure and arterial stiffness in HFpEF patients with different levels of obesity.

Before the 21st century, Heart failure with preserved ejection fraction (HFpEF) was considered as a disease with simple diastolic dysfunction, but after the 21st century, HFpEF was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Other studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between blood pressure and arterial stiffness in HFpEF patients with different levels of obesity.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Heart Failure With Preserved Ejection Fraction

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult aged \>=18years old; * Diagnosed with HFpEF. Diagnostic criteria including: 1. left ventricular ejection fraction ≥50%； 2. with the symptoms and/or signs of heart failure； 3. BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL； 4. at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction Exclusion Criteria: * LVEF less than 45% at any time; * Severe liver failure; * Other causes of shortness of breath, such as severe pulmonary disease or severe chronic obstructive pulmonary disease; * Primary pulmonary hypertension; * Severe valvular disease of the left heart; * Chronically bedridden or incapacitated; * Age \<18 years old.

Outcomes

Primary Outcomes

Arterial stiffness

The arterial stiffness of HFpEF patients, for example brachial ankle pulse wave velocity, ardioankle vascular index and so on.

Time frame: On admission

The level of blood pressure

The level of systolic and diastolic blood pressure of heart failure patients with preserved ejection fraction.

Time frame: On admission

Secondary Outcomes

The change from baseline in quality of life

Measured by Minnesota living with heart failure questionnaire. The score ranges from 0 to 105. The higher score means the worse health-related quality of life.

Time frame: 6 months

The re-hospitalization rate of heart failure