The majority of all new prostate cancer cases are diagnosed in men aged \> 70 years, with the highest incidence in men aged \> 90 years. Management options for localized prostate cancer include active surveillance in patients with low-risk disease, radical prostatectomy or external beam radiation therapy. In previous studies, hypofractionated prostate cancer irradiation regimens have been shown to represent a highly effective treatment option for prostate cancer. However, patients aged 75 years or older were underrepresented in most trials resulting in the lack of a robust evidence base. The proposed study will evaluate radiation-induced toxicity as well as outcome after hypofractionated external beam radiotherapy in prostate cancer patients aged 75 years or older.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
23
Hypofractionated radiotherapy in prostate cancer patients
Medical University of Graz
Graz, Austria
Acute radiation - induced toxicity
Toxicity score using Common Terminology for Adverse Events (CTCAE)
Time frame: Measurement at the last 1 day of radiotherapy
Acute radiation - induced toxicity
Toxicity score using Common Terminology for Adverse Events (CTCAE)
Time frame: Measurement 3 months after completion of radiotherapy
Overall survival
Analysis of survival
Time frame: At 1, 2, 3 , 4, 5 years after completion of radiotherapy
Recurrence (biochemical)
Assessed by measurement of prostate specific antigen (PSA)
Time frame: At 1, 2, 3 , 4, 5 years after completion of radiotherapy
Recurrence (local)
Assessed by magnetic resonance imaging (MRI), positron emission tomography (optional)
Time frame: At 1, 2, 3 , 4, 5 years after completion of radiotherapy
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