Study to Evaluate the Efficacy of SDP-4 in Subjects With Dry Eye Disease (DED) (SDP-4-CS202)

Inclusion Criteria: * Have DED in both eyes, as supported by a subject-reported history of daily symptoms of dryeye for ≥ 6 months prior to Visit 1/Screening requiring the use of artificial tears. * Total score ≥ 40 and ≤ 70 on the SANDE questionnaire at Visits 1 and 2. * Tear break-up time (TBUT) of ≤ 6 seconds in both eyes at Visits 1 and 2. * Anesthetized Schirmer's test tear volume ≥ 3 mm and \<10 mm in both eyes (only at Visit 1). * Best-corrected visual acuity (BCVA) of +0.7 logMAR or better in each eye as assessed by logMAR chart at Visits 1 and 2. Exclusion Criteria: * Ocular surface corneal disease other than DED. * Diagnosis of Sjögren's disease. * Lid margin disorder other than meibomian gland dysfunction (MGD) * Presence of any ocular condition (e.g., pterygium) that in the Investigator's opinion could affect study parameters. * Any previous reconstructive or cosmetic eyelid surgery * Any previous invasive glaucoma and/or corneal surgery * Corneal refractive surgery in the 12 months prior to Visit 1/Screening. * Cataract extraction within 90 days prior to Visit 1/Screening. * Cauterization of the punctum or punctal plug (silicone or collagen) insertion or removal within 30 days prior to Visit 1/Screening or planned during the study. * Contact lens wear. * Use of ophthlamic corticosteroids, NSAIDs, antibiotics, antihistamines, IOP lowering medication, in the 30 days prior to Visit 1/Screening * Serious systemic disease or uncontrolled medical condition that in the judgment of the Investigator could confound study assessments