Participants under general anesthesia will be randomly treated with an adjusted dose dopamine or norepinephrine to elevate 10% of mean arterial pressure. Systemic hemodynamic data is recorded by PRAM and the change of cardiac index is compared between groups.
After intubation under general anesthesia, radial arterial is cannulated and pressure transducer is connected to MostCare(core technique PRAM). CI, SVRI, SVI, SVV, dp/dt and HR are recorded before and after a infusion of dopamine or norepinephrine to elevate 10% of mean arterial pressure. Changes of these hemodynamic data are compared.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
to treat hypotension under general anesthesia with norepinephrine
to treat hypotension under general anesthesia with dopamine
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China
changes of cardiac index
the differences of cardiac index between after and before the intervention (l/min/m2)
Time frame: 20 minutes
changes of stroke volume index
the differences of stroke volume index between after and before the intervention (ml/m2)
Time frame: 20 minutes
changes of systemic vascular resistance index
the differences of systemic vascular resistance index between after and before the intervention(dyne ∙ sec ∙ m2/cm5)
Time frame: 20 minutes
changes of the maximal slope of systolic upstroke
the differences of the maximal slope of systolic upstroke between after and before the intervention(mmHg/ms)
Time frame: 20 minutes
changes of heart rate
the differences of heart rate between after and before the intervention (bpm)
Time frame: 20 minutes
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