Evaluation of the Immune Response to SARS-CoV-2 Among Patients With Covid-19 in Costa Rica

Inclusion Criteria: Recruitment of cases Eligibility criteria Inclusion criteria Potential participants will be deemed eligible if they are: * Diagnosed with Covid-19 disease by a positive PCR test in Costa Rica since March 2020 * Able to communicate with study personnel (or parents for children under 12); * Able and willing to provide a blood sample (or parents); * Not planning to move put of the study area in the next 12 months Exclusion criteria Potential participants will be excluded or deferred from enrollment if: * They are in critical clinical condition precluding enrollment at the discretion of the treating clinicians (deferral) * The clinician determining eligibility in agreement with the principal investigator considers that there is a reason that precludes participation; * The participant or her parent/legal guardian, as applicable, does not have an identification document. Enrollment of active cases Most of the cases of Covid-19 are treated at CCSS hospitals or clnics, where the it is a disease of mandatory reporting. Personnel of the Social Security or Ministry of Health will inform the potential participant case about the study and ask if they are willing to be contacted by study personnel to receive further information. The intention is to recruit all cases with the disease registered in Costa Rica. Enrollment of recovered cases Recovered cases are subjects previously diagnosed with Covid-19 via a positive PCR test who were considered recovered because they had two consecutive negative PCR tests. The first cases was diagnosed in March 2020. They will be contacted and recruited at home based on the registration lists of the CCSS and the Ministry of Health, their eligibility criteria and consent procedures will be similar to those of the active cases, but their specimen collection will be different Community control group selection and enrollment Inclusion criteria Potential participants will be deemed eligible if they are: * Able to communicate with study personnel (or parents for children under 12); * Able and willing to provide a blood sample (or parents); * Not planning to move out of the study area in the next 12 months Exclusion criteria Potential participants will be excluded or deferred from enrollment if: * They have incapacitating or other conditions impeding participation as determined by the study team * The participant or her parent/legal guardian, as applicable, does not have an identification document.