The investigators conduct an RCT to explore the efficacy of esmolol in patients with septic shock and sepsis.
Severe sepsis, septic shock, and their complications have become the major healthcare problem that affects millions of people each year, resulting in high mortality rates. Septic responses have an extremely complex chain of events including inflammatory and anti-inflammatory processes, humoral and cellular reactions, and cardiocirculatory abnormalities. Esmolol may have some potential in treating septic shock and sepsis. The investigators conduct an RCT to explore the efficacy of esmolol in patients with septic shock and sepsis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
120
REE
Resting energy expenditure
Time frame: Day 7 after enrollment
28-day mortality rate
28-day mortality rate
Time frame: Day 28 after enrollment
HR control rate
target heart rate control rate
Time frame: 24 hours after enrollment
Vasoactive drug administration dose
Vasoactive drug administration dose
Time frame: Day 1/3/7 after enrollment
Concentration of Lac
Concentration of lactic acid
Time frame: Day 1/3/7 after enrollment
O2ER
oxygen extraction rate
Time frame: Day 1/3/7 after enrollment
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