compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients and in normal weight patients.
compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients. compare the effectiveness of dexamethasone given in 4 mg and 8 mg doses in obese patients with 4 mg doses of dexamethasone in normal weight patients. 4 mg iv dexamethasone will be administered to normal weight patients at induction of anesthesia. This group will be classified as the control group. In obese patients (BMI\>30 kg/m2), one group will receive 4 mg dexamethasone and other group will receive 8 mg dexamethasone at induction. Patients will receive general anesthesia with volatile anesthetics and tramadol will be administered IV at the end of surgery. Postoperative nausea and vomiting, postoperative pain, blood glucose, wound infection, time to oral intake, hospital stay will be compared.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
150
dexamethasone 4 mg will be administered at induction of anesthesia for postoperative nausea and vomiting proflaxis to normal weight patients.
dexamethasone 4 mg will be administered at induction of anesthesia for postoperative nausea and vomiting proflaxis to obese patients
dexamethasone 8 mg will be administered at induction of anesthesia for postoperative nausea and vomiting proflaxis to obese patients
DiskapiYBERH
Ankara, Turkey (Türkiye)
RECRUITINGpostoperative nausea and vomiting (PONV)
The primary outcome is the overall incidence of PONV during the first 24 h, defined as any episode of vomiting or nausea.Nausea will be measured using an 11-point verbal rating scale (VRS) running from 0 (no nausea) to 10 (the worst nausea imaginable). We will define severe PONV as nausea with a score of at least 4 on the VRS, or vomiting.
Time frame: PONV scores wİll be record during the first 24 hours
postoperative pain: 11-point VRS
Pain intensity will be measured using a simple 11-point VRS running from 0 (no pain) to 10 (unbearable pain), at rest and on mobilisation (asking the patient to cough).
Time frame: Pain will be assessed during the first 24 hours
oral intake
patients will be asked first oral fluid intake time charge criteria.
Time frame: during the first 24 hours
blood glucose
Fingerprick capillary blood glucose concentrations will be measured
Time frame: at 6 and 10 hours after administration of dexamethasone
Length of Hospital Stay
the time will be recorded when patients are discharged home
Time frame: during the first 24 hours
wound infection
Patients will be telephone on the 30th postoperative day and questioned in terms of wound infection
Time frame: postoperative 30th day
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