This trial will investigate whether patiens admitted with an acute exacerbation of chronic obstructive lung disease and pulmonary hypertension will benefit from a targeted pharmacological treatment.
During admittance due to acute exacerbation of chronic obstructive lung disease will patience have an echocardiography to examine their pulmonary pressure. If patient have a tricuspidal return gradient above 40 mmHg, they will receive treatment with a phosphordiesterase-5-inhibitor, Sildenafil.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
250
Sildenafil in standard dosage
Bispebjerg University Hospital
Copenhagen, Denmark
Herlev-Gentofte Hospital
Copenhagen, Denmark
Hvidovre Hospital
Copenhagen, Denmark
Nordsjællands Hospital
Hillerød, Denmark
Odense Universitetshospital
Time alive and out of hospital
Time frame: 365 days
Time to "prednisolon and/or antibiotica"-needing exacerbation of COPD or death
Time frame: 365 days
Death within 90 days
Time frame: 90 days
Death within 1 year
Time frame: 365 days
Alive and without exacerbation of COPD on day 365
Time frame: 365 days
Clinical cure
Time frame: 14 days
Number of readmissions due to exacerbations of COPD
Time frame: 365 days
Number of days with non-invasive ventilation (NIV) or respirator during admittance
Time frame: 14 days
Delta Pa(O2)
Time frame: 4 days
Delta Pa(CO2)
Time frame: 4 days
Delta(pH)
Time frame: 4 days
Change in FEV1
Time frame: 90 days
Change in COPD Assesment Test (CAT)
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Odense, Denmark
Time frame: 29 days
Change in Body Mass Index (BMI)
Time frame: 90 days
Delta(TR-gradient)
Time frame: 4 days