Serum Biomarkers Associated With Postpartum T2DM in Women With GDM

First Affiliated Hospital, Sun Yat-Sen University3,099 enrolled

Overview

Gestational diabetes mellitus (GDM) is commonly linked to the development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with GDM in order to find novel biomarkers for T2DM.

GDM, a common complication of pregnancy, affects 17.8% of pregnancies worldwide per year. Women with a history of GDM have an approximately 7-fold higher risk for developing T2DM in the future than women without GDM. However, data on the factors associated with the development of T2DM in women with GDM are not widely available.

Study Type

OBSERVATIONAL

Enrollment

3,099

Conditions

Gestational Diabetes

Interventions

OTHER

There is no intervention in this study.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women who were dignosed GDM. * Women with singleton pregnancy. * Give birth in the First Affiliated Hospital in Sun Yat-sen University. Exclusion Criteria: * Women who were diagnosed PGDM. * Younger than 18 years old. * Older than 45 years old. * Multiple pregnancy. * Diagnosed DM before. * Complicationg other diseases, like hypertension, thyroid diseases, etc. * Taking any drug affect glucose and lipid metabolism.

Locations (1)

Obstetrics and Gynechology Department of the 1st affiliated hospital of Sun Yat-sen University

Guangzhou, Guangdong, China

Outcomes

Primary Outcomes

T2DM

Women with GDM develop T2DM in postpartum.

Time frame: 4-6 weeks.

Secondary Outcomes

IGT

Women with GDM were impaired glucose intolerance in postpartum.

Time frame: 4-6 weeks.

Data from ClinicalTrials.gov

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