The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases
A total of 80 non-smokers with systemically healthy, including 40 patients with severe chronic periodontitis and 40 periodontally health subjects were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay (ELISA).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
80
Asymmetric dimethylarginine (ADMA)
Serum Concentration (pg/mL)
Time frame: At the 3rd months after non-surgical periodontal treatment
Endothelial nitric oxide synthase (eNOS)
Serum Concentration (pg/mL)
Time frame: At the 3rd months after non-surgical periodontal treatment
Homocysteine (Hcy)
Serum Concentration (nmol/mL)
Time frame: At the 3rd months after non-surgical periodontal treatment
Monocyte chemoattractant protein-1 (MCP-1)
Serum Concentration (ng/mL)
Time frame: At the 3rd months after non-surgical periodontal treatment
Clinical periodontal parameter
Clinical attachment level (mm)
Time frame: At the 3rd months after non-surgical periodontal treatment
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