Bleeding after Mohs micrographic surgery for skin cancer is a low risk complication that can occur. This study aims to determine the effect of a drug, often used to reduce bleeding, called tranexamic acid when applied topically to the skin wound after surgery.
To perform a prospective randomized controlled trial to determine the hemostatic effect of TXA soaked gauze (intervention) versus normal saline soaked gauze (control) when applied to granulating defects in the setting of Mohs micrographic surgery. Patients meeting inclusion criteria will be randomized into two arms once enrolled in the study on the day of their Mohs micrographic surgery (MMS). One arm will serve as the control group and will receive normal saline soaked telfa pads to the wound bed upon completion of MMS. A second arm will receive TXA 25mg/ml at a volume of 1ml/cm2 soaked telfa pads to wound bed upon completion of MMS. In both arms, the telfa pads will have a standard pressure dressing placed overtop.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
124
tranexamic acid diluted to concentration of 25ml/mg
0.9% sodium chloride
University of Missouri-Columbia
Columbia, Missouri, United States
Frequency of Postoperative Hemorrhagic Complications
Number of patients who call to report postoperative bleeding
Time frame: three days
Rate of Clinic Evaluations of Postoperative Hemorrhagic Complications
The number of patients who return to clinic with postoperative bleeding
Time frame: three days
Rate of Treatment Interventions for Postoperative Hemorrhagic Complications
The number of patients who are treated for postoperative bleeding
Time frame: three days
Types of Postoperative Hemorrhagic Complications
postoperative bleeding complications will be defined as arterial bleed, venous oozing, or organized blood clot/hematoma
Time frame: three days
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