The Effect of Desflurane on Postopertative Cognitive Dysfunction

Beijing Chao Yang Hospital100 enrolled

Overview

The purpose of this study is to determine the effect of desflurane on postoperative cognitive dysfunction

Postoperative cognitive dysfunction is a common complication during postoperative period，especially in elderly patients. It is characterized by cognitive decline, inattention and abnormal mental status following surgery. The presence of postoperative cognitive dysfunction is independently associated with poor recovery, increased hospital length of stay and increased mortality. Desflurane is a widely used volatile anesthetic, associated with shorter emergence times than other volatile anesthetics. This study aims to access the effect of desflurane in preventing postoperative cognitive dysfunction.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

100

Conditions

Postoperative Cognitive Dysfunction Postoperative Delirium

Interventions

DesﬂuraneDRUG

Investigators administrated desflurane with target of BIS 40-60 during the maintenance of anesthesia

PropofolDRUG

Investigators administrated propofol with target of BIS 40-60 during the maintenance of anesthesia

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 1\. Written consent given * 2\. Scheduled to undergo elective non-cardiac surgeries under general anesthesia * 3\. ASA Physical Score I-III Exclusion Criteria: * 1\. Patients with a history of neurological disease, such as Alzheimer disease. * 2\. Patients with a history of psychiatric disease * 3\. Patients with a medication history of antipsychotic drugs. * 4\. Unable to complete neuropsychological testing including patients with severe visual or hearing impairment. * 5\. Patients with preoperative delirium. * 6\. Patients who have severe adverse events, such as cardiac arrest. * 7\. Patients who preoperative MMSE score are below 20; * 8\. Patients who undergo second operation in a short period.

Locations (1)

Beijing Chaoyang Hospital, Capital Medical University

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Incidence of postoperative cognitive dysfunction

Screening of the patients regarding an postoperative cognitive dysfunction by TICS-M.TICS-M is assessed at 30 days after surgery

Time frame: on the 30th day after surgery

Secondary Outcomes

Incidence of postoperative delirium

Screening of the patients regarding a postoperative delirium by The Confusion Assessment Method for The Intensive Care Unit (CAM-ICU)

Time frame: 1-7days after surgery, on the 30th day after surgery

Postoperative Pain

Visual Analogue Scale will be used to assess postoperative pain of patients. Numerical rating scale ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst pain.

Time frame: Within 3 days after surgery

EEG frequency spectrum

Electroencephalography will be recorded at different points of time as follows and EEG characteristics including power in alpha, beta, theta, delta, gamma, spectrum will be extracted using MATLAB: 1. Five minutes before anesthesia introduction 2. During the entire operation 3. At discharge from post-anesthesia care unit (PACU)

Time frame: 5 minutes before anesthesia introduction to 5 minutes before discharge from PACU

Mortality

Time frame: Within 30 days after surgery

Length of Hospital stay

Time frame: From the date of admission until discharged from hospital, within 30 days

Hospital readmission

Hospital readmission during the follow up

Time frame: Within 30 days after surgery

Data from ClinicalTrials.gov

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