The Impact of Premorbid Illnesses on the Risk of ICU Admission and Short-term Outcome

Uppsala University9,905 enrolled

Overview

The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring intensive care unit (ICU) -care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish adult respiratory distress syndrome (ARDS) -cohort.

The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring ICU-care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish ARDS-cohort.

Study Type

OBSERVATIONAL

Enrollment

9,905

Conditions

Sepsis Corona Virus Infection

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: ° Individual registered in the Swedish intensive care registry (SIR) with COVID-19 Before 27 May 2020. or * Individual registered in the SIR with Severe sepsis or septic chock 2011-2016. or * Individual registered in the SIR with ARDS 2011-2016. Exclusion Criteria: * Age below 18 years * Individual registered in the Swedish intensive care registry without a personal identification number

Outcomes

Primary Outcomes

Risk factors of ICU care COVID-19/Sepsis

In a binary logistics model with the outcome Sepsis or COVID-19 the OR for several comorbidities are determined.

Time frame: Five years preceding ICU admission to ICU admission

Risk factors of ICU care COVID-19/ARDS

In a binary logistics model with the outcome ARDS or COVID-19 the OR for several comorbidities are determined.

Time frame: Five years preceding ICU admission to ICU admission

Risk factors of ICU mortality COVID-19/Sepsis

In a Cox proportional hazards model with the outcome ICU-mortality the hazard ratio (HR) for the interaction between several comorbidities and a binary variable COVID-19/Sepsis are determined.

Time frame: Five years preceding ICU admission to ICU discharge

Risk factors of ICU mortality COVID-19/ARDS

In a Cox proportional hazards model with the outcome ICU-mortality the HR for the interaction between several comorbidities and a binary variable COVID-19/ARDS are determined.