Pradefovir Treatment for the Patients With Chronic Hepatitis B Virus Infections: a Phase3 Study

Inclusion Criteria: * Age from 18 to 65 years old, male or female. * Meets the diagnosis and treatment standards of chronic hepatitis B( HBsAg or HBV DNA positive over 6 months, or diagnosed by liver biopsy. * For HBeAg positive, HBV DNA equal or over 20000 IU/ml; for HBeAg negative ,HBV DNA equal or over 2000 IU/ml. * ALT level between 1.2 ULN to 10 UNL. * Treatment naive or experienced when any nucleos(t)ide analogs or interferons stopped over 6 months. * Use of effective contraceptive measures if procreative potential exists. * Written informed consent. Exclusion Criteria: * Allergic to study drug,metabolite product or excipient. * Evidence of hepatic decompensation such as Child-Pugh B or C, with previous gastroesophageal variceal haemorrhage, hepatic encephalopathy, ascites * Suspected or confirmed hepatocellular carcinoma, or AFP\>50μg/L. * Other liver diseases (such as Chronic alcoholic hepatitis, drug-induced hepatitis, autoimmune liver disease). * Resistant to antiviral drugs (adefovir or tenofovir). * Concommitant disease of severe heart, blood, respiratory and central nervous system diseases. * Chronic kidney diseases, or Ccr\<60ml/min at screening. * Abnormal hematological and biochemical parameters at screening: White blood cell count less than 3.0×109/L，or neutrophil count less than 1.5×109/L，or platelet count less than 80×109/L，or total bilirubin more than 2ULN，or the prolong of PT more than 3s. * Positive-HCV or positive-HIV. * Severe bone disease (such as osteomalacia, chronic osteomyelitis, osteogenesis imperfecta, rickets) or multiple fractures. * History of pancreatitis or malignancy within 5 years (excluding cervical epithelial carcinoma, squamous epithelial carcinoma, or basal cell carcinoma of the skin that was clinically cured within 5 years of diagnosis). * Plan to receive or have already had an organ transplant. * Subject with disabilities as prescribed by law (blindness, deafness, deafness, deafness, mental disorders, etc.). * History of alcohol or drug abuse within the last 1 year. * Pregnant or lactating women. * Participated in any clinical trial or taken any IMP (investigational medical product) within 3 months prior to the trial. * Other cases that could not be enrolled in the judgement of the investigators.