For most of the patients with limited-stage SCLC, thoracic radiotherapy combined with chemotherapy is the standard treatment at present. However, the optimal dose / fraction of thoracic radiotherapy for limited-stage SCLC is still in controversial.This study is designed as a prospecitive randomized non-inferiority trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
300
Thoracic radiotherapy (45 Gy/30 fractions) for the Hyperfractionated Arm and prophylactic cranial irradiation (25 Gy/10 fractions).
Thoracic radiotherapy (45 Gy/15 fractions) for the Hypofractionated Arm and prophylactic cranial irradiation (25 Gy/10 fractions).
Etoposide will be administered IV 100mg/m2 on days 1-3, 22-24, 43-45 and 64-66.
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
RECRUITINGProgression-free survival
PFS, defined as the time from the date of randomization to the first date of documented objective progression disease or of death from any cause.
Time frame: 2 years
Overall survival
OS, measured from the date of randomization to the date of death from any cause.
Time frame: 5 years
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Cisplatin will be administered IV 80mg/m2 on days 1, 22, 43 and 64.